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Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering

Piero O. Bonetti, MD^*, Stephanie H. Wilson, MBBS^*, Martin Rodriguez-Porcel, MD^*, David R. Holmes, Jr, MD, FACC^*, Lilach O. Lerman, MD, PhD and Amir Lerman, MD, FACC^*,*

^* Division of Cardiovascular DiseasesRochester, Minnesota, USA
Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA

View larger version (17K): [in a new window]   Figure 1 (Upper) Anterior wall myocardial perfusion at baseline and in response to intravenous adenosine in the three experimental groups. (Lower) Relative change of anterior wall myocardial perfusion in response to intravenous adenosine in the three experimental groups (compared to baseline). HC = hypercholesterolemic pigs; HC+S = hypercholesterolemic pigs receiving simvastatin; N = normocholesterolemic pigs. *p < 0.01 versus N and HC+S.

View larger version (18K): [in a new window]   Figure 2 (Upper) Anterior wall myocardial perfusion at baseline and in response to intravenous dobutamine in the three experimental groups. (Lower) Relative change of anterior wall myocardial perfusion in response to intravenous dobutamine in the three experimental groups (compared to baseline). HC = hypercholesterolemic pigs; HC+S = hypercholesterolemic pigs receiving simvastatin; N = normocholesterolemic pigs. *p < 0.05 vs. N and HC+S.

View larger version (15K): [in a new window]   Figure 3 (Upper) Anterior wall microvascular permeability index at baseline and in response to intravenous adenosine in the three experimental groups. (Lower) Relative change of anterior wall microvascular permeability index in response to intravenous adenosine in the three experimental groups (compared to baseline). HC = hypercholesterolemic pigs; HC+S = hypercholesterolemic pigs receiving simvastatin; N = normocholesterolemic pigs. *p < 0.001 vs. N and HC+S.

View larger version (15K): [in a new window]   Figure 4 (Upper) Anterior wall microvascular permeability index at baseline and in response to intravenous dobutamine in the three experimental groups. (Lower) Relative change of anterior wall microvascular permeability index in response to intravenous dobutamine in the three experimental groups (compared to baseline). HC = hypercholesterolemic pigs; HC+S = hypercholesterolemic pigs receiving simvastatin; N = normocholesterolemic pigs. *p < 0.05 vs. N.