Endothelial dysfunction of peripheral arteries in patients with immunohistologically confirmed myocardial inflammation correlates with endothelial expression of human leukocyte antigens and adhesion molecules in myocardial biopsies
Katja B. Vallbracht, MD*,*,
Peter L. Schwimmbeck, MD*,
Bettina Seeberg, MD*,
Uwe Kühl, MD, PhD* and
Heinz-Peter Schultheiss, MD*
* Free University Berlin, Berlin, Germany
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Figure 1 Myocardial biopsies with normal (left panel) versus enhanced (right panel) expression of endothelial cell adhesion molecules, as determined by immunohistology. Magnification x 400.
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Figure 2 Endothelium-dependent, flow-mediated vasodilation (FMD) (left panel) and glyceroltrinitrate endothelium-independent vasodilation (GTN-MD) (right panel) in peripheral arteries in patients with myocardial inflammation (MC) as compared with patients with normal myocardial biopsies (Control). Significant difference for FMD (p < 0.001); no significant difference for GTN-MD.
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Figure 3 Endothelium-dependent, flow-mediated vasodilation (FMD) in peripheral arteries in relation to endothelial expression of human leukocyte antigen (HLA)-1, HLA-DR and intercellular adhesion molecule (ICAM) in myocardial biopsies of patients with myocardial inflammation. Significant differences (p < 0.05).
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Figure 4 Endothelium-dependent, flow-mediated vasodilation (FMD) in peripheral arteries in relation to endothelial activation (sum score) in myocardial biopsies (Co). Significant correlation (r –0.656, p < 0.001). MC = myocardial inflammation.
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