The effects of acute and chronic amiodarone on activation patterns and defibrillation threshold during ventricular fibrillation in dogs
Jian Huang, MD, PhD*,*,
Jonathan L. Skinner, MD ,
Jack M. Rogers, PhD ,
William M. Smith, PhD,
William L. Holman, MD, FACC and
Raymond E. Ideker, MD, PhD, FACC*
* Cardiac Rhythm Management Laboratory, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Cardiac Rhythm Management Laboratory, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
Cardiac Rhythm Management Laboratory, Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
Cardiac Rhythm Management Laboratory, Department of Physiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
View larger version (237K):
[in a new window]
|
Figure 1 Snapshots of re-entrant activation during ventricular fibrillation (VF) episodes in control (A), acute (B) and chronic amiodarone (C) animals. Each colored pixel is an electrode site at which dV/dt <0.5 V/s sometime during the 5-ms interval represented by each frame. The black numbers show the time in milliseconds from the onset of the analysis interval for the corresponding frame 15 s after VF induction. Different colored pixels indicate distinct isolated wavefronts with re-entrant circuits shown in red. The arrows indicate the direction of wavefront movements. The re-entrant wavefronts rotate counterclockwise in A and C and clockwise in B. The core perimeter in A is smaller than in B or C. The wavefronts are more fragmented and complex in A than in B or C.
|
|
|
