This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Palmerini, T. Articles by Coller, B. S. Search for Related Content PubMed PubMed Citation Articles by Palmerini, T. Articles by Coller, B. S.

Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates

Tullio Palmerini, MD^*, Mark A. Nedelman, MS, Lesley E. Scudder, BSc, Marian T. Nakada, PhD^||, Robert E. Jordan, PhD^||, Susan Smyth, MD, PhD, Ronald E. Gordon, PhD, John T. Fallon, MD, PhD and Barry S. Coller, MD^,*

^* Istituto di Cardiologia, Policlinico S. Orsola, University of Bologna, Bologna, Italy
Primedica Corporation, Worcester, Massachusetts, USA
Medicine, New York, New York, USA
Pathology, Mount Sinai Medical School, New York, New York, USA
^|| Centocor, Malvern, Pennsylvania, USA

View larger version (64K): [in a new window]   Figure 1 Histologic assessment of stented blood vessels from a control animal (Number 1) (A) and an abciximab-treated animal (Number 5) (B). Some of the cut stent struts (S) remain in the sections (black rectangles) and in some areas the spaces occupied by the stent struts can be identified (unoccupied rectangles). Sections were stained with hematoxylin and eosin. Left column is x12.5 magnification, the center column x100 magnification and the right column is x400 magnification. E/F = erythrocytes and fibrin; L = leukocytes; M = smooth muscle in the media of the blood vessel; P = platelet thrombi.

View larger version (103K): [in a new window]   Figure 2 Electron micrographs of stented blood vessels from one control animal (Number 1) (A and B) and one abciximab-treated animal (Number 5) (C and D). An exuberant platelet aggregate is present in A; thin fibrin strands with a thicker layer of fibrin and platelet aggregates with an adherent neutrophil are present in B; in C and D a single layer of spread platelets (arrows) adhere directly to the damaged blood vessel wall. Original magnifications are x2,600 in A, x1,600 in B, x2,400 in C and x11,000 in D. IEL = internal elastic lamina.

View larger version (63K): [in a new window]   Figure 3 Immunohistochemistry of sections from a control animal (Number 1) and an abciximab-treated animal (Number 5). Original magnifications are x100 in A and x400 in B to F. The measurement bar refers to B to E.