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J Am Coll Cardiol, 2002; 40:304-310
© 2002 by the American College of Cardiology Foundation
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Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure

Mariantonietta Cicoira, MD*,*, Luisa Zanolla, MD*, Andrea Rossi, MD*, Giorgio Golia, MD*, Lorenzo Franceschini, MD*, Giovanna Brighetti, MD*, Paolo Marino, MD* and Piero Zardini, MD*

* Dipartimento di Scienze Biomediche e Chirurgiche, Sezione di Cardiologia Università degli Studi di Verona, Verona, Italy



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  		Figure 1 Dose-dependent effects of spironolactone on left ventricular ejection fraction (LVEF), peak oxygen consumption (PVO2) and plasma renin levels in patients with chronic heart failure treated with 25 mg and 50 mg of the drug and in the control group. Variables are expressed as absolute differences from follow-up and baseline evaluation.

 
 
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