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Acetylcysteine and contrast agent-associated nephrotoxicity

Carlo Briguori, MD, PhD^*,*, Fiore Manganelli, MD^*, Pierfranco Scarpato, MD^*, Pietro Paolo Elia, MD^*, Bruno Golia, MD^*, Guido Riviezzo, MD^*, Stefano Lepore, MD^*, Mariateresa Librera, MD^*, Bruno Villari, MD^*, Antonio Colombo, MD, FACC and Bruno Ricciardelli, MD^*

^* Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Naples, Italy
Laboratory of Interventional Cardiology, "Vita e Salute" University School of Medicine, San Raffaele Hospital, Milan, Italy

View larger version (15K): [in a new window]   Figure 1 Serum creatinine concentration at baseline (solid bar) and at 48 h (open bar) after contrast dye administration in patients treated with acetylcysteine and hydration (Acetylcysteine Group) and in those treated with hydration alone (Control Group). Brackets represent the standard deviation. There was no statistically significant interaction between the changes in the serum creatinine concentration from baseline and the treatment strategy (F = 0.026, p = 0.87) by the two-way analysis of variance for repeated measures.

View larger version (17K): [in a new window]   Figure 2 Change in creatinine concentration (Crea) from baseline, plotted as a function of the amount of contrast dye administered in the acetylcysteine group. The horizontal dashed line represents Crea = 0; the vertical dashed line represents the cutoff value (140 ml) for small and large amounts of contrast dye.