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J Am Coll Cardiol, 2002; 40:271-277
© 2002 by the American College of Cardiology Foundation
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Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy

V.íctor G. Dávila-Román, MD, FACC*{ddagger},*, Giridhar Vedala, MD*{ddagger}, Pilar Herrero, MS{dagger}, Lisa de las Fuentes, MD*{ddagger}, Joseph G. Rogers, MD, FACC{ddagger}, Daniel P. Kelly, MD, FACC{ddagger}§ and Robert J. Gropler, MD, FACC{dagger}{ddagger}

* Cardiovascular Imaging and Clinical Research Core Laboratory, Washington University School of Medicine, St. Louis, Missouri, USA
{dagger} Cardiovascular Division, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
{ddagger} Center for Cardiovascular Research, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
§ Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA



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  		Figure 1 Positron emission tomography (PET) imaging protocol to assess myocardial metabolism. After a 12-h overnight fast, all subjects underwent a PET imaging protocol (starting at 8:00 AM) to measure myocardial blood flow; myocardial oxygen consumption; myocardial glucose uptake and utilization; and myocardial fatty acid uptake, utilization, and oxidation.

 


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  		Figure 2 Myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy (IDCM). Patients with IDCM exhibited significantly lower rates of myocardial fatty acid utilization and myocardial fatty acid oxidation and significantly higher rates of myocardial glucose utilization compared with normal subjects.

 




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