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Left ventricular remodeling early after aortic valve replacement: differential effects on diastolic function in aortic valve stenosis and aortic regurgitation

Hildo J. Lamb, PhD^*,*,1, Hugo P. Beyerbacht, MD, Albert de Roos, MD^*, Arnoud van der Laarse, PhD, Hubert W. Vliegen, MD, Ferre Leujes, MD, Jeroen J. Bax, MD and Ernst E. van der Wall, MD

^* Radiology, Leiden, The Netherlands
Cardiology, Leiden University Medical Center, Leiden, The Netherlands

View larger version (17K): [in a new window]   Figure 1 The left ventricular mass index (LVMI)/left ventricular end-diastolic volume index (LVEDVI) of 12 patients with aortic valve stenosis and 7 patients with aortic regurgitation, before (PRE) and after (POST) valve replacement, compared with 10 control subjects. Mean values are displayed with standard deviation bars. *p < 0.05 versus control subjects; p < 0.05 before surgery versus after surgery (paired two-tailed t test); p < 0.05 aortic stenosis versus aortic regurgitation (pre vs. pre or post vs. post).

View larger version (24K): [in a new window]   Figure 2 (A) The maximum acceleration slope of early diastolic filling corrected for cardiac output (E accel peak/CO), and (B) the maximum deceleration slope of early diastolic filling corrected for cardiac output (E decel peak/CO) of 12 patients with aortic valve stenosis and 7 patients with aortic regurgitation, before (PRE) valve replacement and 9 ± 3 months after (POST) valve replacement, compared with 10 control subjects. The mean values are displayed with standard deviation bars. *p < 0.05 versus control subjects; p < 0.05 before surgery versus after surgery (paired two-tailed t test); p < 0.05 aortic stenosis versus aortic regurgitation (pre vs. pre or post vs. post).