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Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia

Michael H. Davidson, MD, FACC^*,*, Thomas McGarry, MD, FACC, Robert Bettis, MD, Lorenzo Melani, MD, PhD, Leslie J. Lipka, MD, PhD, FACC, Alexandre P. LeBeaut, MD, Ramachandran Suresh, PhD, Steven Sun, PhD, Enrico P. Veltri, MD, FACC Ezetimibe Study Group

^* Chicago Center for Clinical Research, Chicago, Illinois, USA
Oklahoma Foundation for Cardiovascular Research, Oklahoma City, Oklahoma, USA
Clinical Research Advantage, Edmonds Family Medicine Clinic, Edmonds, Washington, USA
Schering-Plough Research Institute, Kenilworth, New Jersey, USA

View larger version (29K): [in a new window]   Figure 1 Study design. *Q1 = first qualifying LDL-C value using the Friedewald calculation; Q2 = second qualifying LDL-C value using the Friedewald calculation; blood samples for Q1 and Q2 were collected at least one week apart. Randomization to double-blind treatment occurred at Visit 4. NCEP = National Cholesterol Education Program.

View larger version (22K): [in a new window]   Figure 2 Percentage change in direct low-density lipoprotein cholesterol (A), high-density lipoprotein cholesterol (B), and triglyceride (C) concentrations from baseline to end point. EZE = ezetimibe; Simva = simvastatin. Nonfilled columns = Simva; filled columns = Simva + EZE. In (A), the asterisk denotes p < 0.01, combination versus statin alone.

View larger version (29K): [in a new window]   Figure 3 Mean percent change from baseline in plasma concentration of direct low-density lipoprotein cholesterol (LDL-C) over time and at end point. EZE = ezetimibe; Simva = simvastatin.