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Early statin therapy restores endothelial function in children with familial hypercholesterolemia

Saskia de Jongh, MD^*,,*, Marc R. Lilien, MD^,, Jos op’t Roodt, MSc, Erik S. G. Stroes, MD, PhD, Henk D. Bakker, MD, PhD^* and John J. P. Kastelein, MD, PhD

^* Emma Children’s Hospital, AMC, Amsterdam, Netherlands
Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands
Wilhelmina Children’s Hospital, Utrecht, Netherlands

View larger version (32K): [in a new window]   Figure 1 Flow-mediated dilation (FMD) (%) placebo versus simvastatin (familial hypercholesterolemia [FH]) at baseline and 28 weeks. Striped bar = baseline; white bar = 28 weeks. *p < 0.0001 vs. baseline; p < 0.05, FMD placebo vs. FMD simvastatin.