HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marzilli, M. Articles by Fedele, S. Search for Related Content PubMed PubMed Citation Articles by Marzilli, M. Articles by Fedele, S.

Platelet glycoprotein IIb/IIIa receptor blockade and coronary resistance in unstable angina

Mario Marzilli, MD^*,*, Gianmario Sambuceti, MD, Roberto Testa, MD and Silvio Fedele, MD

^* University of Siena, Siena, Italy
Institute of Clinical Physiology CNR, Pisa, Italy

View larger version (9K): [in a new window]   Figure 1 The coronary flow reserve (CFR) (left) and fractional flow reserve (FFR) (right) responses to abciximab and percutaneous transluminal coronary angioplasty (PTCA). Abciximab improved CFR but not FFR, indicating a greater effect of the drug on coronary microvascular function than on stenosis severity. Data are shown as average values ± SEM. *p < 0.05 vs. baseline. °p < 0.01 vs. baseline and abciximab.

View larger version (13K): [in a new window]   Figure 2 Plots of coronary flow reserve (CFR) (y axis) and fractional flow reserve (FFR) (x axis) in all patients before treatment (left), during abciximab infusion (center), and after stenting (right). No correlation was observed between these two descriptors of stenosis severity. After stenting, the persistence of abnormal flow reserve was not caused by persistence of a pressure drop along the epicardial segment.

View larger version (11K): [in a new window]   Figure 3 Effect of abciximab on epicardial (left) and microvascular (right) coronary resistance. Data are shown as average values ± SEM before treatment (open circles connected by solid line), after abciximab (open squares connected by dashed line), and after stenting (solid triangles connected by dotted line). Abciximab limited the increase of epicardial resistance induced by hyperventilation and significantly reduced microvascular resistance in the jeopardized coronary vascular bed under all study conditions. *p < 0.05 vs. corresponding baseline. °p < 0.01 vs. corresponding condition without abciximab. p < 0.01 vs. corresponding condition after abciximab.