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Circadian variation of blood pressure and endothelial function in patients with essential hypertension

a comparison of dippers and non-dippers

Yukihito Higashi, MD, PhD^*,*, Keigo Nakagawa, MD, Masashi Kimura, MD, Kensuke Noma, MD, Keiko Hara, MD, Satoshi Sasaki, MD, Chikara Goto, RTP, MS, Tetsuya Oshima, MD, PhD, Kazuaki Chayama, MD, PhD and Masao Yoshizumi, MD, PhD^*

^* Department of Cardiovascular Physiology and Medicine, Hiroshima, Japan
Department of Medicine and Molecular Science, Hiroshima, Japan
Division of Physical Therapy, Institute of Health Sciences, Hiroshima, Japan
Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan

View larger version (19K): [in a new window]   Figure 1 Line graphs show the forearm blood flow (FBF) response to intra-arterial acetylcholine (top panel) and isosorbide dinitrate (bottom panel) infusion in patients with dipper and non-dipper essential hypertension.

View larger version (13K): [in a new window]   Figure 2 Bar graphs show the 24-h urinary excretion of nitrite/nitrate (NOx) and cGMP in patients with dipper and non-dipper essential hypertension.

View larger version (19K): [in a new window]   Figure 3 Line graphs show the forearm blood flow (FBF) response to intra-arterial acetylcholine infusion in the presence of the nitric oxide synthase inhibitor NG-monomethyl-l-arginine (L-NMMA) in patients with dipper and non-dipper essential hypertension.