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Interventricular and intraventricular dyssynchrony in idiopathic dilated cardiomyopathy

A prognostic study with fourier phase analysis of radionuclide angioscintigraphy

Laurent Fauchier, MD, PhD^*, Olivier Marie, MD^*, Danielle Casset-Senon, MD^,*, Dominique Babuty, MD, PhD^*, Pierre Cosnay, MD^* and Jean Paul Fauchier, MD, FACC^*

^* Services de Cardiologie B et , Centre Hospitalier Universitaire Trousseau, Tours, France
Médecine Nucléaire, Centre Hospitalier Universitaire Trousseau, Tours, France

View larger version (31K): [in a new window]   Figure 1 Correlation between hemodynamic status and left intraventricular dyssynchrony (right) and lack of correlation between hemodynamic status and interventricular (Inter V) delay (left). EF = ejection fraction; LV = left ventricle.

View larger version (29K): [in a new window]   Figure 2 Major cardiac events (cardiac death or heart transplantation) according to ventricular dyssynchrony. (Upper) Cardiac events according to interventricular (IV) delay. (Middle) Cardiac events according to left intraventricular dyssynchrony. (Lower) cardiac events according to right intraventricular dyssynchrony. CI = confidence interval; CV = cardiovascular; FU = follow-up; LV = left ventricle; RV = right ventricle; SD = standard deviation.

View larger version (36K): [in a new window]   Figure 3 Example of phase analysis of equilibrium radionuclide-gated blood pool angiography in two patients. (Upper). Low dyssynchrony in both ventricles, interventricular (Inter V) delay = 39 ms, no event during follow-up. (Lower). Marked dyssynchrony in both ventricles, low interventricular delay (18 ms), sudden death at 24th month. LAO = left anterior oblique; LV = left ventricle; RR = mean duration of all normal-to-normal intervals on 24-h ambulatory electrocardiogram; RV = right venticle; SD = standard deviation.