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The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease

Udho Thadani, MD, FACC^*,*, William Smith, MD, FACC, Stephen Nash, MD, FACC, Neville Bittar, MD, FACC, Stephen Glasser, MD, FACC^||, Puneet Narayan, MD, FACC^¶, Richard A. Stein, MD, FACC^#, Sharon Larkin, RN^**, Arthur Mazzu, PhD^**, Robert Tota, MD, FACC, Kenneth Pomerantz, PhD and Pavur Sundaresan, MD, PhD^**

^* Oklahoma University, Health Sciences Center, and Veterans Affairs Medical Center, Cardiology Section, Oklahoma City, Oklahoma, USA
New Orleans Center for Clinical Research, New Orleans, Louisiana, USA
Syracuse Preventive Cardiology, Syracuse, New York, USA
Gemini Scientific, Madison, Wisconsin, USA
^|| University of Minnesota, School of Public Health, Minneapolis, Minnesota, USA
^¶ Veterans Affairs Medical Center, Washington, DC, USA
^# Brooklyn Hospital Center, Department of Cardiology, Brooklyn, New York, USA
^** Bayer Corporation, Department of Clinical Pharmacology, West Haven, Connecticut, USA
Bayer Corporation, Department of Medical Affairs, West Haven, Connecticut, USA
Bayer Corporation, Department of Scientific Relations, West Haven, Connecticut, USA

View larger version (23K): [in a new window]   Figure 1 Diagramatic representation of study design. ETT = exercise tolerance test.

View larger version (18K): [in a new window]   Figure 2 Effects of vardenafil (V) 10 mg and placebo (PLA) on exercise parameters. Open bars = placebo group; solid bars = vardenafil group. LS = least-square.