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Effects of nitroglycerin treatment on baroreflex sensitivity andshort-term heart rate variability in humans

^a Division of Cardiology, Department of Medicine, Mount Sinai Hospital, and the University Health Network Hospitals, Toronto, Canada.

View larger version (20K): [in a new window]   Figure 1 The effect of nitroglycerin (GTN) treatment on baroreflex sensitivity. The slopes of the relationship between spontaneous changes in systolic blood pressure (SBP) and reflex changes in the immediately following RR interval are presented. Up sequences are presented in the upper panel, while down sequences are presented in the lower panel. Pretreatment values (visit 1, solid lines) are compared with post-GTN treatment (visit 2, dashed lines). Thick lines represent the median value for the group on each visit; thinner lines represent the interquartile range.

View larger version (9K): [in a new window]   Figure 2 Left: Overall (up and down sequences) baroreflex sensitivity (BRS) before and after treatment with transdermal nitroglycerin (GTN) or no therapy in the two groups. Right: Corresponding changes in SD of RR intervals (RRSD) in the two groups. Dashed lines = control group; solid lines = GTN group; empty circles = visit 1; solid circles = visit 2. *p < 0.05; analysis of covariance (GTN vs. control group).