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Oral conjugated equine estrogen increases plasma von Willebrand factor in postmenopausal women

^* Cardiology Division and Center for Women’s Health, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA

View larger version (20K): [in a new window]   Figure 1 The percent change after oral conjugated equine estrogen (CEE) or transdermal estrogen on plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (t-PA), and von Willebrand factor (vWF), compared with baseline. For oral CEE, the test result of the percent change (p value by analysis of variance [ANOVA]) was p = 0.08 for PAI-1, p < 0.004 for t-PA, and p = 0.03 for vWF. For transdermal estrogen, the test result of the percent change (p value by ANOVA) was not significant: p = 0.34 for PAI-1; p = 0.23 for t-PA; and p = 0.24 for vWF. Solid bars = PAI-1; hatched bars = t-PA; and open bars = vWF.