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Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction

Simon R. Dixon, MBChB, FRACP^*,*, Robert J. Whitbourn, MBBS, FRACP, Michael W. Dae, MD, FACC, Eberhard Grube, MD, Warren Sherman, MD, FACC^||, Gary L. Schaer, MD, FACC^¶, J. Stephen Jenkins, MD, FACC^#, Donald S. Baim, MD, FACC^**, Raymond J. Gibbons, MD, FACC, Richard E. Kuntz, MD, FACC, Jeffrey J. Popma, MD, FACC, Thanh T. Nguyen, DO^* and William W. O’Neill, MD, FACC^*

^* William Beaumont Hospital, Royal Oak, Michigan, USA
St. Vincent’s Hospital, Melbourne, Australia
University of California San Francisco, San Francisco, California, USA
Heart Center Siegburg, Siegburg, Germany
^|| Beth Israel Medical Center, New York, New York, USA
^¶ Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois, USA
^# Alton-Oschner Medical Center, New Orleans, Louisiana, USA
^** Brigham and Women’s Hospital, Boston, Massachusetts, USA
Mayo Clinic, Rochester, Minnesota, USA

View larger version (33K): [in a new window]   Figure 1 Diagram of the endovascular cooling system.

View larger version (16K): [in a new window]   Figure 2 Mean core body temperature in patients treated with endovascular cooling (mean ± SD shown). CCU = coronary care unit.

View larger version (20K): [in a new window]   Figure 3 Final infarct size at 30 days in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction with or without endovascular cooling (measured using 99mTc-sestamibi single photon emission computed tomography imaging). Infarct size is shown according to initial Thrombolysis In Myocardial Infarction (TIMI) flow grade in the infarct vessel (• = assigned infarct size for patients who died; = median infarct size for group). LV = left ventricle.