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A long-term perspective on the protective effects of an early invasive strategy in unstable coronary artery disease

Two-year follow-up of the FRISC-II invasive study

B. o Lagerqvist, MDPhD^*,*, Steen Husted, MDPhD, Fredrik Kontny, MDPhD, Ulf Näslund, MDPhD, Elisabeth Ståhle, MDPhD^||, Eva Swahn, MDPhD^¶, Lars Wallentin, MDPhD^* FRISC-II Investigators

^* Department of Cardiology, University Hospital, Uppsala, Sweden
Department of Cardiology, University Hospital, Aarhus, Denmark
Heart and Lung Centre, Ullevål University Hospital, Oslo, Norway
Department of Cardiology, Heart Centre, University Hospital, Umeå, Sweden
^|| Department of Thoracic Surgery, University Hospital, Uppsala, Sweden
^¶ Department of Cardiology, University Hospital, Linköping, Sweden

View larger version (28K): [in a new window]   Figure 1 Probability of death (A), myocardial infarction (B), and death or myocardial infarction (C) in the invasive (n = 1,222, continuous broad line) and noninvasive (n = 1,235, dotted narrow line) groups, illustrated by Kaplan-Meier (1 – survival) curves.

View larger version (25K): [in a new window]   Figure 2 Probability of death (A), myocardial infarction (B), and death or myocardial infarction (C) in the invasive (continuous broad line) and noninvasive (dotted narrow line) groups in the period from 12 months until the last follow-up contact, illustrated by Kaplan-Meier (1 – survival) curves. The p value was derived by the log-rank test between the two groups.

View larger version (16K): [in a new window]   Figure 3 Timing of spontaneous myocardial infarctions (MIs) or death in percutaneous coronary intervention (PCI)-treated patients with (n = 64, continuous line) or without (n = 726, broken line) PCI-related MIs.

View larger version (17K): [in a new window]   Figure 4 Probability of "spontaneous" myocardial infarction (MI) in the invasive (continuous broad line) and noninvasive (dotted narrow line) groups, illustrated by Kaplan-Meier (1 – survival) curves. See text for explanation. The p value was derived by the log-rank test between the two groups.

View larger version (32K): [in a new window]   Figure 5 Probability of death (A), myocardial infarction (B), and "spontaneous" myocardial infarction (C) in the invasive cohort with percutaneous coronary intervention as the first invasive procedure (n = 530, small dotted line at bottom), with coronary artery bypass graft surgery as the first invasive procedure (n = 425, thick short and long dotted line), and without any revascularization (n = 267, continuous narrow line), and the noninvasive cohort (n = 1,235, broken narrow line), illustrated by Kaplan-Meier (1 – survival) curves. The p value was derived by the log-rank test between the three different treatments in the invasive cohort.