Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes
A TACTICS-TIMI 18 substudy
Marc S. Sabatine, MD, MPH*,*,
David A. Morrow, MD, MPH*,
Christopher P. Cannon, MD*,
Sabina A. Murphy, MPH ,
Laura A. Demopoulos, MD ,
Peter M. DiBattiste, MD,
Carolyn H. McCabe, BS*,
Eugene Braunwald, MD* and
C. Michael Gibson, MD, MS
* TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Harvard Clinical Research Institute, Boston, Massachusetts, USA
Merck and Co., West Point, Pennsylvania, USA
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Figure 1 Thrombolysis In Myocardial Infarction (TIMI) flow grade (TFG) (A) and extent of coronary artery disease (B) in relation to baseline white blood cell (WBC) count, categorized as low (<25th percentile), intermediate (25th to 75th percentiles), and high (>75th percentile). MultiVD = multivessel disease; 1VD = single vessel disease; 0VD = no significant disease.
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Figure 2 Mortality at six months (A) and cumulative mortality incidence curves (B) in relation to baseline white blood cell (WBC) count, categorized as low (<25th percentile), intermediate (25th to 75th percentiles), and high (>75th percentile).
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Figure 3 Mortality at six months in relation to both baseline white blood cell (WBC) count and C-reactive protein (CRP) level, categorized as low WBC count (<25th percentile) plus low CRP level ( 1.5 mg/dl), high WBC count (>25th percentile) plus low CRP level, and any WBC count plus high CRP level (>1.5 mg/dl).
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