JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
 QUICK SEARCH:   [advanced]


     


J Am Coll Cardiol, 2002; 40:133-141
© 2002 by the American College of Cardiology Foundation
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kario, K.
Right arrow Articles by Shimada, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kario, K.
Right arrow Articles by Shimada, K.

U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives

Orthostatic hypertension as a new cardiovascular risk factor

Kazuomi Kario, MD, PhD, FACC*,*, Kazuo Eguchi, MD*, Satoshi Hoshide, MD*, Yoko Hoshide, MD*, Yuji Umeda, MD*, Takeshi Mitsuhashi, MD, PhD* and Kazuyuki Shimada, MD, PhD*

* Department of Cardiology, Jichi Medical School, Tochigi, Japan



View larger version (30K):

[in a new window]
 
Figure 1 U-curve relationship between orthostatic blood pressure (BP) change and silent cerebral infarcts in elderly subjects with sustained hypertension. The odds ratios (mean and 95% confidence interval [CI]) for silent cerebral infarcts: (A: 0 = subjects with no infarct; 1 = subjects with one or more infarcts) or for silent multiple cerebral infarcts (B: 0 = subjects with fewer than 3 infarcts; 1 = subjects with three or more infarcts) were adjusted for age (years), gender (0 = female, 1 = male), body mass index (kg/m2), smoking status (0 = nonsmoker, 1 = current smoker), presence/absence of hyperlipidemia (0 = none, 1 = present), and 24-h systolic BP (mm Hg) using multiple logistic regression analysis (Q3 = the reference group).

 


View larger version (59K):

[in a new window]
 
Figure 2 Effect of alpha-adrenergic blocking on orthostatic blood pressure change. The dotted bars show the supine blood pressure (upper edge = systolic blood pressure; lower edge = diastolic blood pressure) and the solid bars show the orthostatic blood pressure during tilting test. The values within the arrows show the orthostatic blood pressure change (systolic/diastolic) by tilting test. The baseline orthostatic blood pressure increase was significantly higher in the orthostatic hypertension group than in the normal group (systolic blood pressure/diastolic blood pressure: 24/8.6 mm Hg vs. 1.5/2.5 mm Hg, both p < 0.01).

 





HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2002 by the American College of Cardiology Foundation.