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Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study

Cecilia Linde, MD, PhD^*,*, Christophe Leclercq, MD, PhD, Steve Rex, MD, Stephane Garrigue, MD, Thomas Lavergne, MD^||, Serge Cazeau, MD^¶, William McKenna, MD^#, Melissa Fitzgerald, MBBS^**, Jean-Claude Deharo, MD, Christine Alonso, MD, Stuart Walker, MD, Frieder Braunschweig, MD^*, Christophe Bailleul, PhD, Jean-Claude Daubert, MD on behalf of the MUltisite STimulation In Cardiomyopathies (MUSTIC) Study Group

^* Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
Department de Cardiologie, CHU, Rennes, France
Department of Cardiology, Harefield Hospital, Harefield, United Kingdom
Hôpital Cardiologique du Haut Levêque, Bordeaux, France
^|| Department de Cardiologie, HEGP, Paris, France
^¶ Department of Cardiology, InParys, Saint-Cloud, France
^# St George’s Hospital, St George’s, United Kingdom
^** Derriford Hospital, Plymouth, United Kingdom
Service de Cardiologie, Hôpital Sainte-Marguerite, Marseille, France
Department de Recherche Clinique, ELA Recherche, Le Plessis-Robinson, France

View larger version (32K): [in a new window]   Figure 1 Study profile. Number of patients active in the study at each follow-up between inclusion and the 12 months in the sinus rhythm (left side) and atrial fibrillation (right side) groups. The reasons for study exits during the crossover phase of the study have been published elsewhere (9). BiV = biventricular; ICD = implantable cardioverter defibrillator; VVIR = rate adaptive ventricular inhibited pacing.

View larger version (21K): [in a new window]   Figure 2 The QRS duration over time. (A) Solid lines represent values during spontaneous rhythm and dotted lines those during biventricular (BiV) pacing in the sinus rhythm group. (B) For the atrial fibrillation group, solid lines represent values during right ventricular pacing at a rate of 70 beats/min and dotted lines those during BiV pacing. CO = cardiac output; M3 = three months; M6 = six months; M9 = nine months; M12 = 12 months; NoP = inactive pacing; RV = right ventricle.