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Vascular remodeling during healing after myocardial infarction in the dog model

Effects of reperfusion, amlodipine and enalapril

Bodh I. Jugdutt, MD, FACC^*,*, Vijayan Menon, BSc^*, Dinender Kumar, PhD^* and Halliday Idikio, MD

^* Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Department of Pathology, University of Alberta, Edmonton, Alberta, Canada

View larger version (23K): [in a new window]   Figure 1 Diagram showing the method used for tissue sampling. LAD = left anterior descending coronary artery; LCX = left circumflex coronary artery; LV = left ventricular.

View larger version (35K): [in a new window]   Figure 2 Effect of treatments on CVF (A, B), PVF (C,D) and the media/lumen ratio and media thickness (E,F). Data on vessels with areas 5 to 20 x 104 µm2 are shown and pooled for hearts with or without reperfusion (E,F).

View larger version (24K): [in a new window]   Figure 3 Power function plots of the media/lumen ratio versus blood vessel area. Data were pooled for hearts with or without reperfusion. Note the cluster of points at the lower area range (<20 x 104 µm2). Regression coefficients (r) were 0.83 for the sham group, 0.59 for the placebo, 0.75 for the amlodipine group and 0.33 for the enalapril group.

View larger version (144K): [in a new window]   Figure 4 Typical photomicrographs of noninfarct tissue six weeks after myocardial infarction. Picrosirius-red staining shows collagen as red, and myocytes and other structures as yellow. A2, B2 = polarized light showing collagen as bright yellow or green; A1, A2 = placebo effect; B1, B2 = effect of amlodipine, showing a resistance vessel with an increased area of media, relative to the lumen, and perivascular fibrosis. Arrows indicate vessels. Crystalline material from postmortem arteriograms are seen within the lumen.

View larger version (17K): [in a new window]   Figure 5 Diagram showing changes in the resistance vessel lumen (inner circle) and wall (area between inner and outer circles). The dark area represents perivascular fibrosis. The wall/lumen ratio is nearly similar for enalapril and amlodipine, although the wall area is less with enalapril and greater with amlodipine, compared with placebo.