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Imaging of myocardial infarction: comparison of magnevist and gadophrin-3 in rabbits

J.örg Barkhausen, MD^*,*, Wolfgang Ebert, PhD, J.örg F. Debatin, MD^* and Hanns-Joachim Weinmann, PhD

^* Department of Diagnostic Radiology, University Hospital Essen, Germany
Research Laboratories of Schering AG, Berlin, Germany

View larger version (8K): [in a new window]   Figure 1 Acquisition scheme of the segmented inversion recovery turbo fast low angle shot (IRturboFLASH) sequence. AW = acquisition window; IR = inversion pulse; TD = delay after trigger; TI = inversion time; TReff = effective repetition time; TRmin = minimum repetition time.

View larger version (48K): [in a new window]   Figure 2 Acute transmural infarction (arrows). The area of hyperenhancement on gadophrin-3 (B) and gadophrin-3 plus Magnevist (C) enhanced images closely matches the infarction size defined by triphenyltetrazolium chloride staining (A).

View larger version (46K): [in a new window]   Figure 3 An acute nontransmural infarction (arrows) can clearly be depicted on triphenyltetrazolium chloride staining (A), gadophrin-3 (B) and gadophrin-3 plus Magnevist (C) enhanced images. The area of hyperenhancement is virtually identical on both in-vivo magnetic resonance scans.

View larger version (13K): [in a new window]   Figure 4 Agreement between area of hyperenhancement (mean value of the differences = closed line; ± 2 SD = dotted lines) from gadophrin-3 and gadophrin-3 plus Magnevist enhanced T1-weighted images depicted in a Bland and Altman graph. Average value of the two measurements is plotted along the x-axis; the difference (gadophrin-3 minus gadophrin-3 plus Magnevist) is plotted along the y-axis.

View larger version (99K): [in a new window]   Figure 5 Diastolic (A) and systolic (B) cine magnetic resonance images show thinned myocardium with a lack of systolic wall thickening in an animal with chronic myocardial infarction. The inversion recovery turbo fast low angle shot sequence shows no enhancement 24 h after injection of gadophrin (C), whereas the infarcted myocardium (arrows) appears bright following the injection of gadolinium diethylene-triamino-penta-acetate (D).