This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCully, R. B. Articles by Pellikka, P. A. Search for Related Content PubMed PubMed Citation Articles by McCully, R. B. Articles by Pellikka, P. A.

Outcome after abnormal exercise echocardiography for patients with good exercise capacity

Prognostic importance of the extent and severity of exercise-related left ventricular dysfunction

Robert B. McCully, MB, ChB, FACC^*,*, Veronique L. Roger, MD, FACC^*, Douglas W. Mahoney, MS, Kelli N. Burger, BS, Roger L. Click, MD, PhD, FACC^*, James B. Seward, MD, FACC^* and Patricia A. Pellikka, MD, FACC^*

^* Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
Section of Biostatistics, Mayo Clinic, Rochester, Minnesota, USA

View larger version (25K): [in a new window]   Figure 1 (A) Event-free (cardiac death or nonfatal myocardial infarction) survival of patients according to the response of the left ventricular (LV) end-systolic size to exercise. The one-, three- and five-year event-free survival rates for patients with a decrease in LV end-systolic size in response to exercise were 98.7 ± 0.3%, 95.8 ± 0.7% and 91.1 ± 1.3%, respectively (event rate 1.6%); and for patients with an increase or no change in LV end-systolic size, 98.0 ± 0.6%, 93.7± 1.3% and 86.2 ± 2.6%, respectively (event rate 2.9%). (B) The percentage of LV segments that were severely abnormal immediately after exercise. The one-, three- and five-year event-free survival rates for patients with 0% of LV segments severely abnormal immediately after exercise were 99.3 ± 0.3%, 96.6 ± 0.7% and 93.8 ± 1.3%, respectively (event rate 1.2%); for patients with 1% to 25% of LV segments severely abnormal, 97.7 ± 0.6%, 93.5 ± 1.2% and 91.3 ± 1.6%, respectively (event rate 2.2%); and for patients with >25% of LV segments severely abnormal, 97.8 ± 0.8%, 95.0 ± 1.4% and 75.2 ± 4.8%, respectively (event rate 3.8%).

View larger version (22K): [in a new window]   Figure 2 Event rates per person-year of follow-up for patients with normal exercise echocardiography (data for 1,181 patients with good exercise capacity [9]) and for patients with a decrease and an increase or no change in left ventricular (LV) end-systolic size in response to exercise. MI = myocardial infarction.

View larger version (25K): [in a new window]   Figure 3 Event rates per person-year of follow-up for patients with normal exercise echocardiography (Fig. 2) and for patients with 0%, 1% to 25% and >25% of left ventricular (LV) segments severely abnormal immediately after exercise. MI = myocardial infarction.