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Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension

Ronald J. Raymond, MD^*, Alan L. Hinderliter, MD^*,*, Park W. Willis, IV, MD^*, David Ralph, MD, Edgar J. Caldwell, MD, William Williams, MD, Neil A. Ettinger, MD, Nicholas S. Hill, MD^||, Warren R. Summer, MD^¶, Bennett de Boisblanc, MD^¶, Todd Schwartz, MS^#, Gary Koch, PhD^#, Linda M. Clayton, Pharm D^**, Maria M. Jöbsis, BA^**, James W. Crow, PhD, Walker Long, MD Primary Pulmonary Hypertension Study Group

^* University of North Carolina, Chapel Hill, North Carolina, USA
University of Washington, Seattle, Washington, USA
Maine Medical Center, Portland, Maine, USA
Washington University, St. Louis, Missouri, USA
^|| Rhode Island Hospital, Providence, Rhode Island, USA
^¶ Louisiana State University Medical Center, New Orleans, Louisana, USA
^# Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA
^** GlaxoWellcome Inc., Research Triangle Park, North Carolina, USA
United Therapeutics, Inc., Chapel Hill, North Carolina, USA
Cato Research Ltd., Durham, North Carolina, USA

View larger version (17K): [in a new window]   Figure 1 Kaplan-Meier survival curves for echocardiographic predictors of outcomes. By Cox proportional hazards modeling, right atrial (RA) area index (p = 0.005) and pericardial effusion (p = 0.003) were significant predictors of death; the relationship of diastolic eccentricity index to mortality was of marginal statistical significance (p = 0.074). Right atrial area index (p = 0.012), pericardial effusion (p = 0.017) and diastolic eccentricity index (p = 0.004) were all significant predictors of a composite end point of death or transplantation.