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The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy

John O. Parker, MD, FACC^*,*, John D. Parker, MD, FACC, Robert W. Caldwell, PhD, Bernice Farrell, RN^* and Wayne H. Kaesemeyer, MD

^* Department of Medicine, Queen’s University, Kingston, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GeorgiaUSA

View larger version (45K): [in a new window]   Figure 1 Treadmill walking time to the onset of moderate angina (P2) during the two treatment periods. Open bars indicate treatment period involving transdermal nitroglycerin and placebo. Hatched bars indicate treatment period involving transdermal nitroglycerin and L-arginine. *p < 0.05 versus baseline (0 hour, day 1).