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Antecedent hypertension and heart failure after myocardial infarction

A. Mark Richards, MD, PhD^,*, M. Gary Nicholls, MD, FACC^*, Richard W. Troughton, PhD^*, John G. Lainchbury, MD, John Elliott, MB, ChB, PhD, Christopher Frampton, PhD^*, Eric A. Espiner, MD^*, Ian G. Crozier, MD^*, Timothy G. Yandle, PhD^* and John Turner, MD

^* Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch Hospital, Christchurch, New Zealand
Cardiology, Christchurch Hospital, Christchurch, New Zealand
Nuclear Medicine, Christchurch Hospital, Christchurch, New Zealand

View larger version (16K): [in a new window]   Figure 1 Change (; mean ± SEM) in left ventricular systolic volume (LVESV; top panel), left ventricular diastolic volume (LVEDV; middle panel) and left ventricular ejection fraction (LVEF; bottom panel) between measurements at 24 to 96 h after infarction and a mean of four (three to five) months after infarction in normotensive (solid columns) and hypertensive (cross-hatched columns) patients. *p < 0.05, **p < 0.01, p < 0.001.

View larger version (19K): [in a new window]   Figure 2 Event-free survival curves for postdischarge all-cause mortality (Death; upper panel) and postdischarge heart failure requiring readmission to hospital (Heart Failure; lower panel) in normotensive (NT; single line) and hypertensive (HT; double line) patients after acute myocardial infarction. *p < 0.05, p < 0.001.

View larger version (27K): [in a new window]   Figure 3 Event-free survival curves for postdischarge heart failure requiring readmission to hospital in normotensives (dotted and dashed lines; groups NT1 and NT2) and hypertensives (solid lines; groups HT1 and HT2) according to age (top panel), aminoterminal brain natriuretic peptide (N-BNP) (middle panel) and left ventricular systolic volume (LVESV) (lower panel) equal or below (dotted [NT1] and light solid [HT1] lines) and above (dashed [NT2] and heavy solid [HT2] lines) overall median values. Medians: age = 64.1 years; N-BNP 120 pmol/l; LVESV 78 ml. *p < 0.05, **p < 0.01, p < 0.001.