Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure
Rainer Hambrecht, MD*,*,
Paul Christian Schulze, MD*,
Stephan Gielen, MD*,
Axel Linke, MD*,
Sven Möbius-Winkler, MD*,
Jiangtao Yu, MD*,
J.ürgen Kratzsch, MD ,
Gerhard Baldauf, MD ,
Martin W. Busse, MD||,
Andreas Schubert, PhD ,
Volker Adams, PhD* and
Gerhard Schuler, MD*
* University of Leipzig–Heart Center, Department of Cardiology; Leipzig, Germany
Department of Cardiac Surgery, University of Leipzig–Heart Center, Leipzig, Germany
Department of Radiology, University of Leipzig–Heart Center, Leipzig, Germany
Institute of Clinical Chemistry, Leipzig, Germany
|| Institute of Sport Medicine, Leipzig, Germany
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Figure 1 Representative Western blots for insulin-like growth factor (IGF)-I protein are presented in A. (B) Local expression of IGF-I messenger ribonucleic acid (mRNA). ***p < 0.001 vs. healthy subjects. CHF = chronic heart failure.
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Figure 2 Local expression of insulin-like growth factor (IGF)-I receptor messenger ribonucleic acid (mRNA). CHF = chronic heart failure. ***p < 0.001 vs. healthy subjects.
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Figure 3 Correlation between right lower limb cross-sectional area (CSA) and insulin-like growth factor (IGF)-I messenger ribonucleic acid (mRNA) in skeletal muscle biopsies obtained from the same thigh. A: y = 0.16 x –3.8 (R = 0.75, p = 0.01).
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