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Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia

Ian B. Wilkinson, MA, BM^*, Krishna Prasad, MB, Ian R. Hall, BSc, MB, Anne Thomas, BN, Helen MacCallum, BN^*, David J. Webb, MD, Michael P. Frenneaux, MD and John R. Cockcroft, BSc, MB^,*

^* Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
Department of Cardiology, University of Wales College of Medicine, University Hospital, Cardiff, United Kingdom

View larger version (9K): [in a new window]   Figure 1 Representative ascending aortic waveforms from a young and older subject (Murgo type "C" and "A" waves, respectively); note the prominence of the second systolic peak (*) in the older individual. Augmentation index is defined as the difference between the second and first systolic peaks (P) expressed as a percentage of the pulse pressure (PP).

View larger version (9K): [in a new window]   Figure 2 Box and whisker plots for augmentation index (AIx), augmentation and estimated aortic pulse wave velocity (TR) for the hypercholesterolemia (HC) and control subjects. Solid horizontal lines = median values; error bars = 95% confidence intervals; shaded area = interquartile range. n = 163; *p = 0.01; **p < 0.001.