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Risk of cardiovascular disease in relation to achieved office and ambulatory blood pressure control in treated hypertensive subjects

Paolo Verdecchia, MD, FACC^*,*, Gianpaolo Reboldi, MD, MSc, PhD, Carlo Porcellati, MD^*, Giuseppe Schillaci, MD, Sergio Pede, MD, Maurizio Bentivoglio, MD^*, Fabio Angeli, MD^*, Silvia Norgiolini, MD^* and Giuseppe Ambrosio, MD, PhD, FACC^*

^* Università di Perugia ed Ospedale R. Silvestrini, Dipartimento di Malattie Cardiovascolari, Italy
Università di Perugia, Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Italy
Dipartimento di Medicina Interna, Ospedale di San Pietro Vernotico, Italy
Ospedale di San Pietro Vernotico, Perugia, Italy

View larger version (20K): [in a new window]   Figure 1 Office and 24-h ambulatory blood pressure at entry (black bars) and follow-up (white bars).

View larger version (27K): [in a new window]   Figure 2 Incidence of cardiovascular (CV) disease in treated hypertensive subjects with and without adequate control of ambulatory blood pressure (ABP).

View larger version (29K): [in a new window]   Figure 3 Age-adjusted (Cox model) five-year risk of cardiovascular (CV) disease at different levels of 24-h in-treatment systolic and diastolic blood pressure (BP), diabetes and left ventricular (LV) hypertrophy. The calculated risk corresponds to the median within each quartile.

View larger version (20K): [in a new window]   Figure 4 Age- and risk-factor adjusted five-year risk of cardiovascular (CV) disease with increasing pre-treatment and in-treatment average 24-h blood pressure (BP).