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Cardiac calcification in adult hemodialysis patients

A link between end-stage renal disease and cardiovascular disease?

Paolo Raggi, MD^*,1, Amy Boulay, MPH^,1, Scott Chasan-Taber, PhD^,1, Naseem Amin, MD^¶,1, Maureen Dillon, MA^,1, Steven K. Burke, MD^,1 and Glenn M. Chertow, MD, MPH^#,*,1

^* Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA
GelTex Pharmaceuticals, Inc, Waltham, Massachusetts, USA
Boston Biostatistics, Inc, Cambridge, Massachusetts, USA
^¶ Genzyme, Inc, Cambridge, Massachusetts, USA
^# Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA

View larger version (110K): [in a new window]   Figure 1 The subject in Figure 1A is a 68-year-old healthy female volunteer with calcification in the middle left anterior coronary artery (white arrow) and a total CA calcium score of 45 (approximately 50th percentile for age and gender). The patient with ESRD in Figure 1B is a 70-year-old woman with extensive calcification in the middle and distal left anterior CA (black arrow). The CA calcium score was 374, corresponding to >90th percentile for age and gender.

View larger version (29K): [in a new window]   Figure 2 The prevalence of atherosclerotic vascular disease by CA calcium score category.