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C-reactive protein and angiographic coronary artery disease: independent and additive predictors of risk in subjects with angina

James S. Zebrack, MD^*, Joseph B. Muhlestein, MD, FACC^*,, Benjamin D. Horne, MPH, Jeffrey L. Anderson, MD, FACC^*,* Intermountain Heart Collaboration Study Group

^* Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
Cardiovascular Department, LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah, USA

View larger version (29K): [in a new window]   Figure 1 Cumulative incidence of all-cause mortality or myocardial infarction (MI) during follow-up by coronary artery disease (CAD) score and C-reactive protein (CRP). Among 2,554 patients presenting with stable or unstable angina, the extent of CAD was defined as a CAD score (total number of lesions + total number of moderate and severe coronary vessels). A CAD score of 0 equals a normal angiogram. Subjects with a positive score were divided into quartiles. C-reactive protein was defined as low (<1 mg/dl, 28% of patients), moderately elevated (1.0 to 2.0 mg/dl, 55% of patients) or highly elevated (>2 mg/dl, 17% of patients). The percent of each group with death or MI during follow-up is noted on each column.