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Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia

Fukuoka atherosclerosis trial (FAST)

Yasunori Sawayama, MD, PhD^*, Chie Shimizu, MD^*, Naoyasu Maeda, MD^*, Masafumi Tatsukawa, MD^*, Naoko Kinukawa, MS, Samon Koyanagi, MD, PhD, Seizaburo Kashiwagi, MD, PhD and Jun Hayashi, MD, PhD^*,*

^* General Medicinel, Fukuoka, Japan
Medical Informatics, Kyushu University Hospital, Fukuoka, Japan,
National Kyushu Medical Center, Fukuoka, Japan

View larger version (21K): [in a new window]   Figure 1 Serum lipid levels in the probucol (triangles), pravastatin (squares) and control (circles) groups. Data are presented as the mean value ± SD. *p < 0.05; ***p < 0.001 vs. baseline.

View larger version (15K): [in a new window]   Figure 2 Changes in intima-media thickness (IMT) in the probucol (triangles), pravastatin (squares) and control (circles) groups. Data are presented as the mean value ± SD. *p < 0.05; **p < 0.01 vs. baseline.

View larger version (11K): [in a new window]   Figure 3 Kaplan-Meier estimates of the occurrence of all coronary events. Bold solid line = control group; thin solid line = pravastatin group; broken line = probucol group. There was a significant difference between the control group and probucol groups (*p < 0.05 by the log-rank test).