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Increased plasma levels of the soluble form of fas ligand in patients with acute myocardial infarction and unstable angina pectoris

Masumi Shimizu, MD^*, Keisuke Fukuo, MD^*,*, Shigekazu Nagata, PhD, Toshimitsu Suhara, MD^*, Masashi Okuro, MD^*, Kenshi Fujii, MD, Yorihiko Higashino, MD, Masaki Mogi, MD^*, Yasuko Hatanaka, MD^* and Toshio Ogihara, MD^*

^* Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
Department of Genetics, Osaka University Medical School, Suita, Japan
Sakurabashi-Watanabe Hospital, Sakurabashi, Osaka, Japan

View larger version (20K): [in a new window]   Figure 1 Plasma levels of sFasL on hospital admission in patients with stable and unstable angina pectoris (AP) and patients with acute myocardial infarction (AMI). Blood sampling for measuring the concentrations of soluble Fas ligand (sFasL) were taken from the peripheral vein on admission in all patients.

View larger version (11K): [in a new window]   Figure 2 Correlation of plasma soluble Fas ligand (sFasL) levels with the maximal levels of creatine kinase-MB isoenzyme (CK-MB) (A) and with the cardiac index (B).

View larger version (19K): [in a new window]   Figure 3 Time course of the changes in plasma soluble Fas ligand (sFasL) levels and the differences in sFasL levels between the coronary sinus and peripheral vein. For the time-course experiment, peripheral blood sampling was repeated at 3, 6, 12, 18 and 24 h after admission in five patients with acute myocardial infarction (AMI) (A). Blood samples were collected from the coronary sinus and the peripheral vein at the same time in the same patient with AMI (B). AP = angina pectoris; PTCA = percutaneous transluminal coronary angioplasty.

View larger version (23K): [in a new window]   Figure 4 The Fas ligand (FasL) mRNA expression and soluble Fas ligand (sFasL) release in mononuclear cells isolated from patients with acute myocardial infarction (AMI). Basal levels of FasL mRNA of mononuclear cells isolated from patients with AMI and from the control subjects (A). The mRNA from 1A12 cells (FasL-overexpressing cells) was used as a positive control. Time course changes in sFasL levels after hypoxia in the supernatant from mononuclear cells isolated from patients with AMI (B).