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Angiotensin receptor blockers in heart failure: meta-analysis of randomized controlled trials

Philip Jong, MD^*, Catherine Demers, MD, MSc, Robert S. McKelvie, MD, PhD and Peter P. Liu, MD, FACC^*,*

^* Heart & Stroke/Richard Lewar Centre of Excellence, Division of Cardiology, University Health Network, University of Toronto, Toronto, Canada
Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University, Hamilton, Canada

View larger version (18K): [in a new window]   Figure 1 Comparison of angiotensin receptor blockers versus controls on all-cause mortality. Controls were either placebo or angiotensin-converting enzyme inhibitor (ACEI). Odds ratios (OR) and the 95% confidence intervals (CI) are shown on a logarithmic scale, with box size proportional to the sample size. The diamond represents the pooled effect. Acronyms as in Abbreviations and Acronyms box.

View larger version (35K): [in a new window]   Figure 2 Stratified comparisons of angiotensin receptor blockers (ARB) on all-cause mortality: ARB versus placebo, ARB versus angiotensin-converting enzyme inhibitors (ACEI) and ARB-ACEI combination versus ACEI. Odds ratios (OR) and the 95% confidence intervals (CI) are shown on a logarithmic scale, with box size proportional to the sample size. In each stratum, the diamond represents the pooled effect. Acronyms as in Abbreviations and Acronyms box.

View larger version (10K): [in a new window]   Figure 3 Comparison of angiotensin receptor blockers versus controls on hospitalization for HF. Controls were either placebo or angiotensin-converting enzyme inhibitors. Odds ratios (OR) and the 95% confidence intervals (CI) are shown on a logarithmic scale, with box size proportional to the sample size. The diamond represents the pooled effect. Acronyms as in Abbreviations and Acronyms box.

View larger version (25K): [in a new window]   Figure 4 Stratified comparisons of angiotensin receptor blockers (ARB) on hospitalization for HF: ARB versus placebo, ARB versus angiotensin-converting enzyme inhibitor (ACEI) and ARB-ACEI combination versus ACEI. Odds ratios (OR) and the 95% confidence intervals (CI) are shown on a logarithmic scale, with box size proportional to the sample size. In each stratum, the diamond represents the pooled effect. Acronyms as in Abbreviations and Acronyms box.