HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mahon, N. G. Articles by McKenna, W. J. Search for Related Content PubMed PubMed Citation Articles by Mahon, N. G. Articles by McKenna, W. J.

Immunohistologic evidence of myocardial disease in apparently healthy relatives of patients with dilated cardiomyopathy

Niall G. Mahon, MD^*,*, Brendan P. Madden, MD^*, Alida L. P. Caforio, MD, PhD, Perry M. Elliott, MD^*, Aldwyn J. Haven, BSc^*, Bruce E. Keogh, MD, Michael J. Davies, MD, PhD^* and William J. McKenna, MD^*

^* Department of Cardiological Sciences, St. George’s Hospital Medical School, London, United Kingdom
Division of Cardiology, Department of Experimental and Clinical Medicine, University of Padova, Padova, Italy
Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom

View larger version (12K): [in a new window]   Figure 1 Pedigree of a dilated cardiomyopathy family. Solid symbols = affected individuals; half-solid symbols = asymptomatic relatives with left ventricular enlargement.

View larger version (33K): [in a new window]   Figure 2 Photomicrographs demonstrating expression of intercellular adhesion molecule-1 (A), endothelial staining (B) and double exposure (C) (x40 magnification) in a biopsy from a relative with left ventricular enlargement.

View larger version (13K): [in a new window]   Figure 3 (A) Correlation between quantitative assessment of human leukocyte antigen (HLA)-DR and intercellular adhesion molecule (ICAM)-1 (r = 0.47, p < 0.001). (B) Quantitative expression of HLA-DR in relation to visual assessment (error bars represent 1 SEM). The y axis represents the percentage of endothelial expression. The x axis represents positive (Pos) grade 2+ (moderate intensity) or grade 3+ (high intensity) and negative (Neg) grade 0 (negative) or grade 1+ (weak intensity) by visual assessment. (C) Quantitative expression of ICAM-1 in relation to visual assessment.

View larger version (13K): [in a new window]   Figure 4 Relationship between markers of inflammation and the presence of chronic histologic changes of dilated cardiomyopathy. The y axis represents the percentage of endothelial expression of antigen (intercellular adhesion molecule [ICAM] and human leukocyte antigen [HLA-DR]) or median cell counts (CD68+ and CD3+). The error bars represent 1 SEM. The x axis represents the presence or absence of fibrosis and chronic myopathic changes.