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Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction

Rolf Jenni, MD, MSEE^*, Christophe A. Wyss, MD, Erwin N. Oechslin, MD^* and Philipp A. Kaufmann, MD^,*

^* Department of Echocardiography, Cardiovascular Center, University Hospital, Zurich, Switzerland
Department of Nuclear Cardiology, Cardiovascular Center, University Hospital, Zurich, Switzerland

View larger version (29K): [in a new window]   Figure 1 Mid-ventricular short-axis view of an echocardiographic recording (left) showing septal, inferior and lateral hypertrabeculation and a two-layered structure of the left ventricular myocardium, indicative of noncompaction. The corresponding nongated 13N-ammonia scan (right) shows lateral and inferior irregularities. PET = positron emission tomography.

View larger version (15K): [in a new window]   Figure 2 Comparison between echocardiography and positron emission tomography in patients with isolated ventricular noncompaction. The microcirculatory dysfunction is not confined to noncompacted segments (right and middle), but extends to most myocardial segments with wall motion abnormalities (left). Perfusion defects were assessed in 12 patients (108 segments); quantification was successful in only nine patients (81 segments). CFR = coronary flow reserve.