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J Am Coll Cardiol, 2002; 39:420-427
© 2002 by the American College of Cardiology Foundation
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Absolute blood flow and oxygenconsumption in stunned myocardiumin patients with coronary artery disease

Edward Barnes, MRCP*, Roger J. C. Hall, MD, FRCP*, David P. Dutka, DM, MRCP* and Paolo G. Camici, MD, FESC, FACC, FAHA, FRCP*,*

* MRC Clinical Sciences Centre and Division of Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom



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  		Figure 1 Study protocol demonstrating the relative timings for the positron emission tomography and echocardiographic acquisitions. C15O = 15O-labelled carbon monoxide; H215O = 15O-labelled water; TR = transmission scan; 15O2 = 15O-labelled oxygen.

 


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  		Figure 2 (A) Ejection fraction (%) versus time after peak dobutamine (mean ± 95% confidence interval [CI]). (B) Shortening fraction of dysfunctional and non-dysfunctional remote regions (mean ± 95% CI). SFdysfunction = post-ischemic dysfunction; SFnorm = remote regions not demonstrating post-ischemic dysfunction. *p < 0.001; {dagger}p < 0.05.

 


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  		Figure 3 (A and B) Myocardial blood flow (MBF) to dysfunctional and remote regions at baseline, peak dobutamine and in recovery. Flow is given as raw data (A) and corrected for the rate pressure product (RPP) (MBFcorr = (MBFbaseline/RPP) x 104). (B) All recovery flow = NS compared with baseline except remote uncorrected flow: (*p < 0.001 compared with baseline uncorrected flow). (C) Myocardial oxygen consumption to dysfunctional and remote regions at baseline and in recovery: (*p < 0.001 compared with corresponding baseline value). SFdysfunction = post-ischemic dysfunction; SFnorm = regions not demonstrating post-ischemic dysfunction.

 


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  		Figure 4 (A) Shortening fraction (SF) as a percentage change from baseline (mean ± 95% confidence interval [CI]). *p < 0.001. (B) Peak myocardial blood flow (MBF) (mean ± 95% CI) versus stenosis severity (% of luminal diameter) in nine patients.

 




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