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Initial experience with hyperoxemic reperfusion after primary angioplasty for acute myocardial infarction

Results of a pilot study utilizing intracoronary aqueous oxygen therapy

Simon R. Dixon, MBChB, FRACP^*, Antonio L. Bartorelli, MD, FACC, Pamela A. Marcovitz, MD, FACC^*, Richard Spears, MD, FACC, Shukri David, MD, FACC, Issac Grinberg, MD, FACC, Mansoor A. Qureshi, MD^*, Mauro Pepi, MD, Daniela Trabattoni, MD, Franco Fabbiocchi, MD, Piero Montorsi, MD and William W. O’Neill, MD, FACC^*,*

^* Division of Cardiology, William Beaumont Hospital, Royal Oak, Michigan, USA
Centro Cardiologico Fondazione Monzino IRCCS, Istituto di Cardiologia Università di Milano, Milan, Italy
Providence Hospital and Medical Center, Southfield, Michigan, USA

View larger version (14K): [in a new window]   Figure 1 Infarct vessel Thrombolysis In Myocardial Infarction (TIMI) flow grade: before coronary angioplasty (PTCA), after PTCA and after the aqueous oxygen (AO) infusion.

View larger version (14K): [in a new window]   Figure 2 Global left ventricular ejection fraction immediately after primary percutaneous transluminal coronary angioplasty (baseline) and after hyperoxemic reperfusion with aqueous oxygen (AO). *p = 0.08 (vs. baseline); p < 0.001 (vs. baseline); p < 0.005 (vs. 24 h).

View larger version (13K): [in a new window]   Figure 3 Global wall motion score index (WMSI) immediately after primary percutaneous transluminal coronary angioplasty (baseline) and after hyperoxemic reperfusion with aqueous oxygen (AO). *p < 0.001 (vs. baseline); p < 0.005 (vs. 24 h).

View larger version (13K): [in a new window]   Figure 4 Wall motion score index (WMSI) of infarct and non-infarct zones at baseline and after hyperoxemic reperfusion with aqueous oxygen (AO). Solid triangle = infarct zone; solid square = non-infarct zone. *p < 0.01 (vs. baseline); p = 0.01 (vs. 24 h).