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Plasma atrial natriuretic peptide concentration inversely correlates with left atrial collagen volume fraction in patients with atrial fibrillation

Plasma ANP as a possible biochemical marker to predict the outcome of the maze procedure

Fumiki Yoshihara, MD^*, Toshio Nishikimi, MD^*,,*, Yoshikado Sasako, MD, Jun Hino, PhD^*, Junjiro Kobayashi, MD, Kenji Minatoya, MD, Ko Bando, MD, Yoshio Kosakai, MD^,, Takeshi Horio, MD, Shin-ichi Suga, MD^*, Yuhei Kawano, MD, Hiroaki Matsuoka, MD, Chikao Yutani, MD^||, Hisayuki Matsuo, PhD^*, Soichiro Kitamura, MD, Tohru Ohe, MD^¶ and Kenji Kangawa, PhD^*

^* National Cardiovascular Center Research Institute, Suita, Japan
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Japan
Division of Cardiovascular Surgery and Hypertension, National Cardiovascular Center, Suita, Japan
Division of Cardiovascular Surgery, Takarazuka Citizen’s Hospital, Takarazuka, Japan
^|| Division of Pathology, National Cardiovascular Center, Suita, Japan
^¶ Department of Cardiovascular Medicine, Okayama University Medical School, Okayama, Japan

View larger version (82K): [in a new window]   Figure 1 Masson’s trichrome staining of the excised left atrial appendages under light microscopy and quantification of the collagen volume fraction in the atrial fibrillation (AF) and sinus rhythm (SR) groups.

View larger version (21K): [in a new window]   Figure 2 Correlations between collagen volume fraction and plasma atrial natriuretic peptide (ANP) level (A) and duration of AF(B).

View larger version (21K): [in a new window]   Figure 3 Combined assessment of plasma atrial natriuretic peptide (ANP) level and duration of atrial fibrillation (AF). SR = sinus rhythm.

View larger version (57K): [in a new window]   Figure 4 Representative Northern blots showing collagen type I, type III and atrial natriuretic peptide (ANP) in the excised left atrial appendages in patients with persistent atrial fibrillation after the maze procedure (AF group) and patients with sinus rhythm (SR group). Bar graph shows the summary of findings of Northern blot analysis of atrial collagen type I, type III and ANP messenger RNA in the AF and SR groups.