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J Am Coll Cardiol, 2002; 39:202-209
© 2002 by the American College of Cardiology Foundation
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Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea

L. Katherine Morrison, BS*, Alex Harrison, BS*, Padma Krishnaswamy, MD*, Radmila Kazanegra, MD*, Paul Clopton, MS* and Alan Maisel, MD, FACC*,*

* Division of Cardiology, Veteran’s Affairs Medical Center, and the Department of Medicine, University of California, San Diego, California, USA



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  		Figure 1 B-type natriuretic peptide (BNP) levels of patients diagnosed with congestive heart failure (CHF), baseline left ventricular dysfunction, pulmonary disease, other cardiac disease and other noncardiac, nonpulmonary disease.

 


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  		Figure 2 Receiver operating characteristic curve comparing the sensitivity and specificity of B-type natriuretic peptide (BNP) in differentiating congestive heart failure (CHF) from non-CHF in patients presenting with dyspnea. Selected BNP values are indicated in pg/ml. Listed below the figure are accuracies of various cut-points of BNP. AUC = area under curve and is significant, p < 0.001.

 


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  		Figure 3 Mean ± SD for B-type natriuretic peptide (BNP) values in patients with various types of pulmonary disease. COPD = chronic obstructive pulmonary disease; TB = tuberculosis.

 


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  		Figure 4 B-type natriuretic peptide (BNP) levels in patients with a past history of pulmonary disease but a final diagnosis of acute congestive heart failure (CHF), as well as patients with a past history of CHF but a final diagnosis of acute pulmonary disease. Data are expressed as mean ± SE for BNP values. COPD = chronic obstructive pulmonary disease.

 




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