Dose heterogeneity may not affect the neointimal proliferation after gamma radiation for in-stent restenosis
A volumetric intravascular ultrasound dosimetric study
Akiko Maehara, MD*,
Neil S. Patel, MS ,
Louis B. Harrison, MD,
Neil J. Weissman, MD, FACC*,*,
Anh B. Bui, MD*,
Han-Soo Kim, MD*,
Andrew E. Ajani, MD*,
Marco T. Castagna, MD*,
Taya L. McMillan, MS*,
Nathan Yang, PhD*,
Rosanna Chan, PhD*,
Julliana Pisch, MD,
Harry Quan, MD,
Sou-Tung Chiu-Tsao, PhD,
Ron Waksman, MD, FACC* and
Gary S. Mintz, MD, FACC
* Cardiovascular Research Institute, Washington Hospital Center, Washington DC, USA
Beth Israel Medical Center and St. Luke’s-Roosevelt Hospital Center, New York, New York, USA
Cardiovascular Research Foundation, New York, New York, USA
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Figure 1 Individual dose (D) volume (V) histograms at the adventitia for the entire stent.
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Figure 2 Individual dose (D) volume (V) histograms at the intima for the entire stent.
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Figure 3 The relationship between the neointimal regrowth and Dv90 at adventitia. DV90 = dose delivered to at least 90% of the volume.
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Figure 4 The relationship between the neointimal regrowth and Dv50 intima. DV50 = dose delivered to at least 50% of the volume.
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Figure 5 The relationship between the average neointimal regrowth and entire Dv90 at adventitia.
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Figure 6 The relationship between the average neointimal regrowth and entire Dv50 at intima.
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