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J Am Coll Cardiol, 2002; 39:1937-1942
© 2002 by the American College of Cardiology Foundation
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Dose heterogeneity may not affect the neointimal proliferation after gamma radiation for in-stent restenosis

A volumetric intravascular ultrasound dosimetric study

Akiko Maehara, MD*, Neil S. Patel, MS{dagger}, Louis B. Harrison, MD{dagger}, Neil J. Weissman, MD, FACC*,*, Anh B. Bui, MD*, Han-Soo Kim, MD*, Andrew E. Ajani, MD*, Marco T. Castagna, MD*, Taya L. McMillan, MS*, Nathan Yang, PhD*, Rosanna Chan, PhD*, Julliana Pisch, MD{dagger}, Harry Quan, MD{dagger}, Sou-Tung Chiu-Tsao, PhD{dagger}, Ron Waksman, MD, FACC* and Gary S. Mintz, MD, FACC{ddagger}

* Cardiovascular Research Institute, Washington Hospital Center, Washington DC, USA
{dagger} Beth Israel Medical Center and St. Luke’s-Roosevelt Hospital Center, New York, New York, USA
{ddagger} Cardiovascular Research Foundation, New York, New York, USA



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  		Figure 1 Individual dose (D) volume (V) histograms at the adventitia for the entire stent.

 


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  		Figure 2 Individual dose (D) volume (V) histograms at the intima for the entire stent.

 


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  		Figure 3 The relationship between the neointimal regrowth and Dv90 at adventitia. DV90 = dose delivered to at least 90% of the volume.

 


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  		Figure 4 The relationship between the neointimal regrowth and Dv50 intima. DV50 = dose delivered to at least 50% of the volume.

 


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  		Figure 5 The relationship between the average neointimal regrowth and entire Dv90 at adventitia.

 


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  		Figure 6 The relationship between the average neointimal regrowth and entire Dv50 at intima.

 




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Copyright © 2002 by the American College of Cardiology Foundation.