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Relationship of myocardial remodeling to the genesis of serum autoantibodies to cardiac beta₁-adrenoceptors and muscarinic type 2 acetylcholine receptors in rats

Hui-Rong Liu, MD, PhD^*, Rong-Rui Zhao, MD, PhD^*, Xiang-Ying Jiao, MD, PhD^*, Ying-Yuan Wang, MD, PhD^* and Michael Fu, MD, PhD^,*

^* Laboratory of Cardiovascular Physiology, Shanxi Medical University, Taiyuan, China
Wallenberg Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden

View larger version (34K): [in a new window]   Figure 1 Changes in the frequency of the occurrence of both autoantibodies in the sera, before (pre) and after (post) four weeks of treatment. AB = aortic banding group (n = 24); ADR = adriamycin group (n = 24); Control = control of both experimental groups (n = 48). **p < 0.01 versus control group.

View larger version (22K): [in a new window]   Figure 2 Time course of genesis of both autoantibodies in terms of changes in titers of autoantibodies after aortic banding (AB) (A) and adriamycin (ADR) (B) treatment (only sera positive for autoantibodies are shown).

View larger version (40K): [in a new window]   Figure 3 Chronotropic effects on cultured neonatal rat cardiomyocytes induced by sera positive for the beta1-adrenoceptor (A) or the M2 receptor (B). These effects were respectively abolished by the addition of both receptor antagonists and pre-incubation with both antigenic peptides. PS = positive sera.