Vasodilator signals from the ischemic myocardium are transduced to the coronary vascular wall by pertussis toxin-sensitive g proteins
A new experimental method for the analysis of the interaction between the myocardium and coronary vessels
Kouichi Sato, MD*,
Tatsuya Komaru, MD*,*,
Hiroki Shioiri, MD*,
Satoru Takeda, MD*,
Katsuaki Takahashi, MD*,
Hiroshi Kanatsuka, MD* and
Kunio Shirato, MD, FACC*
* Department of Cardiovascular Medicine, Tohoku University, Graduate School of Medicine, Sendai, Japan
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Figure 1 The detector vessel responses during myocardial ischemia in Protocol 1. Significant dilation was observed at 2, 3, 5 and 10 min after the induction of ischemia. *p < 0.05 compared with baseline.
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Figure 2 The detector vessel (DV) responses during myocardial ischemia in Protocol 2. In contrast to Protocol 1, no significant dilation was observed during ischemia, when the DVs were pretreated with pertussis toxin (100 µg/ml).
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Figure 3 Column graphs showing the detector vessel responses to superfusion of sodium nitroprusside (SNP) (100 µmol/l). In both groups, the vessels were significantly dilated. There was no difference in the magnitude of SNP-induced dilation between Protocols 1 and 2.
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