The effects of hypothermia on human left ventricular contractile function during cardiac surgery
Michael E. Lewis, MB, ChB, BSc, FRCS*,
Abdhul-Hakam Al-Khalidi, PhD ,
John N. Townend, MD, FRCP ,
John Coote, BSc, PhD and
Robert S. Bonser, FRCS, FRCP*,*
* Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom
Department of Physiology, University of Birmingham, Birmingham, United Kingdom
Department of Cardiovascular Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom
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Figure 1 Pressure volume loops from a patient demonstrating a fall in contractility at constant paced heart rate (100 beats/min), with cooling (A = 37°C; B = 33°C). Group 1.
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Figure 2 Change in normalized end systolic elastance from baseline at constant paced heart rate (100 beats/min) with cooling. Group 1. **p < 0.0001.
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Figure 3 Change in normalized stroke work (SW) -end diastolic volume (EDV) relationship from baseline at constant paced heart rate (100 beats/min) with cooling. Group 1. **p < 0.05.
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Figure 4 Change in normalized time to peak ejection rate from baseline at constant paced heart rate (100 beats/min) with cooling. Group 1. **p < 0.05.
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Figure 5 Change in normalized end systolic elastance with changing heart rate at 37°C. Group 2.
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Figure 6 Change in normalized end systolic elastance with changing heart rate at 33°C. Group 2.
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