The healing process of infarct-related plaques
Insights from 18 months of serial angioscopic follow-up
Yasunori Ueda, MD, PhDa,*,
Masanori Asakura, MDb,
Osamu Yamaguchi, MDb,
Atsushi Hirayama, MD, PhDa,
Masatsugu Hori, MD, PhD, FACCb and
Kazuhisa Kodama, MD, PhD, FACCa
a Cardiovascular Division, Osaka Police Hospital, OsakaJapan
b Division of Cardiology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
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Figure 1 Color samples for the grading of yellow plaque.
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Figure 2 Prevalence of yellow plaque at the culprit lesions (A), mean (±SD) color grade of the culprit plaque (B) and prevalence of thrombus at the culprit plaques (C). Yellow plaques remained for as long as 18 months at the culprit lesions of acute MI, although the color grade was reduced significantly and the prevalence was reduced mildly but significantly from one to six months after reperfusion. The prevalence of thrombus was decreased significantly from immediately to one month after reperfusion, and further from one to six months. 0M = immediately after reperfusion; M = month(s) after reperfusion. A: *p < 0.05 vs. 1 M. B: *p < 0.005 vs. 1 M. C: *p < 0.005 vs. 0 M.  p < 0.005 vs. 1 M.
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Figure 3 Prevalence of thrombus (A) and mean (±SD) color grade (B) in patients with HL (solid bars) and patients without HL (hatched bars). The prevalence of thrombus and the mean color grade immediately after reperfusion and at one month were not different between the patients with HL and those without HL. The mean color grade at six months was significantly higher in the patients with HL. 0 M = immediately after reperfusion; M = months after reperfusion. *p < 0.05 vs. patients without HL.
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Figure 4 Prevalence of thrombus (A) and mean (±SD) color grade (B) in patients with DM (solid bars) and patients without DM (hatched bars). The prevalence of thrombus and the mean color grade immediately after reperfusion were not different between the patients with HL and those without HL. The prevalence of thrombus was significantly higher and the mean color grade tended (p = 0.08) to be higher in the patients with DM at one month. The mean color grade at six months was not different between the patients with DM and those without DM. 0 M = immediately after reperfusion; M = months after reperfusion. *p < 0.05 vs. patients without DM.
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