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Increased production of inflammatory cytokines in patients with silent myocardial ischemia

Antonino Mazzone, MD^*,*, Chiara Cusa, MD^*, Iolanda Mazzucchelli, BSc^*, Monia Vezzoli, MD^*, Elena Ottini, MD^*, Roberta Pacifici, BSc, Piergiorgio Zuccaro, MD and Colomba Falcone, MD

^* Department of Internal Medicine, Legnano Hospital, Milan Italy
Clinical Biochemistry Department, National Institute of Health, Rome Italy
Department of Cardiology, IRCCS S. Matteo Hospital, Pavia, Italy

View larger version (17K): [in a new window]   Figure 1 CD11b/CD18 adhesion molecule expression in asymptomatic patients (group A) and in patients complaining of angina pain (group P). Asymptomatic patients express lower level of adhesion molecule both on neutrophils and on monocytes. Open bars = silent ischemia; solid bars = symptomatic ischemia. MESF = molecules of equivalent soluble fluorescein.

View larger version (21K): [in a new window]   Figure 2 Cytokine plasma levels in asymptomatic patients (group A) and in patients complaining of angina (group P); A, anti-inflammatory cytokines; B, proinflammatory cytokines. Open bars = silent ischemia; solid bars = symptomatic ischemia. IFN- = interferon-gamma; IL = interleukin; TGFbeta = transforming growth factor-beta; TNF-alpha = tumor necrosis factor-alpha.