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Modulation of coronary flow velocity reserve by gender, menstrual cycle and hormone replacement therapy

Kumiko Hirata, MD^*, Kenei Shimada, MD^*,*, Hiroyuki Watanabe, MD^*, Takashi Muro, MD^*, Minoru Yoshiyama, MD^*, Kazuhide Takeuchi, MD^*, Takeshi Hozumi, MD and Junichi Yoshikawa, MD, FACC^*

^* Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, Osaka, Japan
Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA

View larger version (15K): [in a new window]   Figure 1 Individual change in serum 17ß-estradiol concentration in the menstrual (M) and follicular (F) phases in premenopausal women (left) and in initial and second studies at two weeks in men (right).

View larger version (16K): [in a new window]   Figure 2 Individual change in coronary flow velocity reserve (CFVR) in the menstrual (M) and follicular (F) phases in premenopausal women (left) and in initial and second studies at two weeks in men (right).

View larger version (15K): [in a new window]   Figure 3 Individual change in coronary flow velocity reserve (CFVR) at baseline and after conjugated estrogen administration.