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Uric acid is closely linked to vascular nitric oxide activity

Evidence for mechanism of association with cardiovascular disease

^a Division of Research and Development, Cooke Pharma, Inc., Belmont, California, USA

View larger version (26K): [in a new window]   Figure 1 Relationship of serum uric acid level (SUA) to flow-mediated vasodilation (FMV) for a population of men and women (n = 458) with and without cardiovascular disease risk factors.

View larger version (17K): [in a new window]   Figure 2 Relationship of flow-mediated vasodilation (FMV) and serum uric acid level (SUA) with degree of cardiovascular disease (CVD) risk. There is a stepwise decrease in FMV and a stepwise increase in SUA with increasing risk. Regression plot of mean values for each risk group forms is nearly linear. The four risk groups are: I = those with no disease or risk factors for cardiovascular disease; II = those with one or more risk factors but no CVD identified by history, physical examination, laboratory analysis or review of medical records; III = those with a diagnosis of CVD but without events; IV = those with a history of events including myocardial infarction and stroke. Values are mean ± SEM. **p < 0.01; ***p < 0.001 for FMV and p < 0.05; p < 0.01 for SUA.

View larger version (26K): [in a new window]   Figure 3 Effect of L-arginine-enriched medical food on flow-mediated vasodilation (FMV) and serum uric acid level (SUA). (A) FMV (n = 111) and (B) SUA (n = 253) before and after intervention designed to enhance vascular NO production. Values are mean ± SEM. **p < 0.01; ***p <0.0001 for overall model by univariate analysis of variance controlled for baseline measures; p values for treatment interaction at time after are given above bars.