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Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype

Catherine H. Pullin, BSc^a, Pauline A. L. Ashfield-Watt, BA^a, Michael L. Burr, MD, FFPHM^a, Zoë E. Clark, MPhil^a, Malcolm J. Lewis, MB, DSc, FESC^a, Stuart J. Moat, PhD, Robert G. Newcombe, PhD, C. Stats, MFPHM, Hilary J. Powers, PhD, Jenny M. Whiting, RGN^a and Ian F. W. McDowell, MD, MRCP, FRCPath^*,a

^a Cardiovascular Sciences Research Group, Wales Heart Research Institute, Cardiff, United Kingdom
Centre for Human Nutrition, Division of Clinical Sciences, Northern General Hospital, Sheffield, United Kingdom
Department of Medical Computing and Statistics, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom

View larger version (21K): [in a new window]   Figure 1 Flow chart detailing the volunteer recruitment procedure. After determination of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype, equal numbers of subjects with each genotype (CC, CT and TT) were allocated to the study.

View larger version (20K): [in a new window]   Figure 2 Time course of brachial artery response to increased blood flow at baseline and after each intervention for the group as a whole. Data are given as the change in brachial artery end-diastolic diameter (mean ± SEM). Open squares = baseline; solid upward triangles = placebo; solid downward triangles = diet; and open diamonds = supplement.